Glibenclamide in ectopic pregnancy Applications

Glibenclamide by increasing insulin levels, or the portal vein directly to the liver, inhibition of hepatic glycogenolysis and gluconeogenesis, reduced hepatic glucose production and output; oral absorption, high protein binding, was 95% after oral administration of 2 to 5 hour plasma concentration peak, continued for 24 hours. T1 / 2 was 10 hours. Metabolized in the liver by the hepatic and renal excretion of approximately 50%.
In ectopic pregnancy in the application: 
Ectopic pregnancy is a common gynecological acute abdomen, the incidence increased significantly in recent years, but increased in patients without a child. With the fast and sensitive β-hCG detection technology to carry out, high-resolution B-application, make the most of unruptured ectopic pregnancy prior to the diagnosis, conservative treatment for drug provided the conditions [1], on the need to retain reproductive function in patients, choice of drugs and the best treatment is a question worth exploring. Conservative treatment of ectopic pregnancy has made great progress, has become a major means of treatment [2], and its advantage is that it not only kills the embryo tissue, without destroying the fallopian tubes, thereby maintaining tubal patency. At present, domestic and conservative about ectopic pregnancy reported that the majority of drug treatment used methotrexate (MTX).
However, methotrexate damage to the body's response to chemotherapy great many side effects. Mifepristone inception, gradually being used in the treatment of ectopic pregnancy, less the number of days for menopause, progesterone levels are relatively lower, mifepristone anti-pregnancy better. In this paper, 50 cases of ectopic pregnancy in patients with methotrexate (methotrexate, MTX) as the control, observation of mifepristone (mifepristone, Mif) the efficacy of treatment of ectopic pregnancy, to explore a safe, effective, convenient, less side effects of treatment.
Object of study and grouping May 1999 ~ October 2003 ectopic pregnancy diagnosed 50 patients hospitalized, the youngest 20 years old, maximum 41 years, mean 27 years, menopause time 38 to 65 days. Diagnosis is based on history, gynecological examination, serum β-hCG and B-ultrasound, except by curettage uterine pregnancy. Medication for: (a) unruptured ectopic pregnancy or tubal pregnancy rupture, but less bleeding; (2) B-ultrasound tubal pregnancy mass diameter 6000U / L and conservative treatment in patients with medication requirements, no taboo mifepristone licenser. (6) liver and kidney functions were normal, peripheral WBC, RBC, PLT were within normal range.


More about:Glibenclamide supplier
From:Chem pharma

What is Cremophor EL?

Traits: according to the number of ethylene oxide molecularcondensation of gradually increased, from the thin oil graduallybecome sticky and even become waxy semisolid.

Use: a nonionic surfactant. Mainly used in aqueous phase emulsifier. Mainly used as pesticide emulsifier and printing pigment dispersing agent.

Preparation or source: from castor oil 1 molar and ethylene oxide20 to 40 moles of shrinkage and.

Product Application:Cremophor EL is the registered brand of BASF Corp. for its adaptation of polyethoxylated brush oil. It is able by reacting 35 moles of ethylene oxide with anniversary birthmark of brush oil. The consistent artefact is a admixture (CAS amount 61791-12-6): the above basic is the actual in which the hydroxyl groups of the brush oil triglyceride accept ethoxylated with ethylene oxide to anatomy polyethylene glycol ethers.Minor apparatus are the polyethyelene glycol esters of ricinoleic acid, polyethyelene glycols and polyethyelene glycol ethers of glycerol.It is acclimated as a bread-and-butter and emulsifier for the water-insoluble drugs or added fat-soluble drugs.It is acclimated in doughy and aqueous formulations.

More about:Cremophor EL supplier

From:Chem pharma

Pharmacological effects on Clemastine Fumarate introduction

Clemastine fumarate is a white or almost white crystalline powder, odorless, slightly bitter taste. Clemastine fumarate (Clemastine Fumarate) is a Swiss Sandoz (Sandoz) company in the 1960s successfully developed antihistamines. Thereafter, in the United States, Japan, Germany, put on the market. This product is a typical, representative of the second generation H1 receptor antagonists, histamine clinically for the treatment cited by the various allergic diseases, is currently the world's best recognized antihistamines world.

Pharmacological effects:
Clemastine fumarate tablets of Shandong Institute of Pharmaceutical Industry in China developed the first of the original four new drugs, new drug to obtain a certificate, also received three years of administrative protection.
After forty years of clinical practice of foreign and domestic clinical validation summary, clemastine fumarate is a fast-acting, long-lasting, efficient, safe and reliable antihistamines. Clemastine fumarate tablets pharmacokinetics in humans showed that the oral absorption fast, effective after 30 minutes, quickly relieve symptoms, one hour after the plasma concentration reached the highest value compared with similar antihistamines such as astemizole, chlorine loratadine contrast, this product is the fastest effective. Its anti-histamine effect sustainable 12 hours, anti-histamine effect 10 times stronger than chlorpheniramine, drowsiness side effects (central role) is minimal. Treatment of allergic rhinitis total effective rate was 98%, the treatment of chronic urticaria urticaria cure rate 61.3%. Clemastine is not only basophils and lung tissue by the release of histamine antagonism, but at high concentrations toxic to cells also have a certain antagonism, drug on allergic diseases has many therapeutic effects. Mainly used in clinical allergic rhinitis, urticaria, eczema and other allergic dermatitis.



More about:Clemastine Fumarate supplier
From:Chem pharma

For the purpose of PVP K90

Purpose:

PVP (PVP K90) as a synthetic water-soluble polymer, a water-soluble polymer of the general nature of the protective colloid effect, film, adhesion, moisture, solubilization, or cohesion, but its most characteristics, and thus subject to people's attention is its excellent solubility and physiological compatibility. In synthetic polymers such as PVP both soluble in water, but soluble in most organic solvents, low toxicity, good physiological compatibility and rare, especially in the pharmaceutical, food, cosmetics these closely related with people's health field, along with its lower prices of raw materials butyrolactone, will demonstrate its good prospects for development. The following is a detailed description of its application areas:
Medicine & Health
PVP has excellent physical inertia, not involved in human metabolism, but also has excellent biocompatibility, skin, mucous membranes, eyes, which do not form any stimulation. From a biological point of view, PVP molecular structure of the protein features a simple model of similar kind of structure, even its water-soluble to some small molecules with the ability of some proteins and can be ammonium sulfate precipitant, trichloroacetic acid, tannic acids and other characteristics of the precipitated proteins and also compatible. So that the PVP is widely used as materials of pharmaceutical preparations, specific applications as follows: ① ② for the preparation of a binder as precipitant ③ Injection cosolvents or crystal formation preventing agent or a coating film-forming agent ④ ⑤ delay, release agents prolong the drug controlled release duration of action of drugs artificial vitreous and cornea ⑥ ⑦ ⑧ PVP iodine surgical dressings disinfectant. In addition, PVP can also be used as a colorant and a X-ray contrast agent; for tablets, granules, liquid drugs and other forms, with detoxification, bleeding, increased concentration of dissolved prevent peritoneal adhesions, to promote sedimentation and so on.
Food processing
PVP itself is not carcinogenic, good food safety, to the specific polyphenol compounds (such as tannins) form a complex in the food processing primarily as beer, fruit juice, wine and other foods clarifying agents and stabilizers.
Daily cosmetics
In PVP, consumption structure, the cosmetics industry in developed countries accounted for 30% to 50%, China accounted for 70% to 80%. Because PVP has a very low toxicity and physiologically inert, it skin, eye irritation, in the field of medicine has a long record of use, so it is safe for cosmetics. In daily use cosmetics, PVP and copolymers with good dispersion and film-forming properties, PVP in the emulsion has a protective colloid can be used for fatty and non-fatty cream that is used for setting lotions, hair sprays and Mount silk styling agent, hair sunscreen agents, shampoo foam stabilizer agents for hair styling wave dispersing agent and the affinity agent. In cream, sunscreen, depilatories adding PVP, can enhance wetting and lubricating effect.
Detergent field
PVP has anti-soil redeposition performance for the preparation of transparent liquid or heavy dirt detergent, the detergent is added PVP has a good anti-turn color effect, and can enhance the washing ability, wash fabric of synthetic detergent to prevent skin irritation, especially for fibers, this performance than carboxymethyl cellulose (CMC) type detergent more prominent. PVP complex with borax, phenol disinfectant cleaner formulation as the active ingredient. PVP with hydrogen peroxide in the solid detergent compound, a bleaching effect of killing bacteria.
Textile
PVP and many organic dyes have a good affinity, which can be used with polyacrylonitrile, esters, nylon, and hydrophobic fibrous materials, synthetic fibers, and to improve dyeability and hydrophilicity.
Paint and color
PVP coated with paint, paint transparent film without affecting the color, to improve the coating and paint gloss and dispersibility, improved thermal stability and can improve the dispersibility of the ink and other inks.
Polymer Technology
Polyvinyl pyrrolidone as a polymer surfactant dispersion in different systems, can be used as dispersants, emulsifiers, thickeners, leveling agents, particle size adjusting agents, anti-redeposition agents, flocculants, solvent and washing agent.
Other aspects
PVP can be used as a gelling agent tertiary oil recovery, enhanced oil oil recovery rate. As a photosensitive material is latex additive helps to reduce the developed image and enhanced degree of coverage. Polymerization process the polymer as a thickening agent, a dispersion stabilizer and adhesion regulating agent. In the paper industry as a dispersing agent in the gasification of acrylamide as a cocatalyst. PVP in the membrane, light-cured resin, laser disc, drag-reducing coatings, building materials, steel and electroplating and other fields are also rising.



More about:PVP K90 supplier
From:Chem pharma

Kollidon 25 product applications

Product name:Kollidon 25

Product Application:Kollidon 25 is a average atomic weight (W28 ,000-34, 000)product.Kollidon 25 is mainly acclimated in tablets, capsules and granules of the adhesive; articulate abeyance stabilizer, film-forming agent, blush area dispersant, thickeners, agitator stabilizers and it is aswell acclimated to advance the bioavailability of baffling drugs.

The acrid Kollidon grades are decidedly acceptable for wet granulation processes in absorption of 1 to 5%, or with band-aid of adhesive or bread-and-butter (e.g. water). Kollidon® 25 and Kollidon® 30 can aswell be acclimated in tabletting processes at concentrations commensurable to absorption in wet granulation processes. All varieties of acrid Kollidon (Kollidon®) are aswell acclimated in ophthalmic preparations. Kollidon® 17 PF, Kollidon® 25 and Kollidon® 30 formulations are frequently acclimated in eye drops, and Kollidon® 90F is adopted in solutions for acquaintance lenses. A different affection of povidone is their adeptness to anatomy complexes with the alive substances, so that they can be an able apparatus to advance the dissolution of abounding drugs.

More about:Kollidon 25 supplier

From:Chem pharma

What is Cremophor ELP？

Abstract:

Cremophor ELP is a conception car acclimated for assorted poorly-water acrid drugs, including the anticancer abettor paclitaxel (Taxol). In adverse to beforehand reports, CrEL is not an apathetic vehicle, but exerts a ambit of biological effects, some of which accept important analytic implications. Its use has been associated with astringent anaphylactoid hypersensitivity reactions, hyperlipidaemia, aberrant lipoprotein patterns, accession of erythrocytes and borderline neuropathy. The pharmacokinetic behaviour of CrEL is dose-independent, although its approval is awful afflicted by continuance of the infusion. This is decidedly important back CrEL can affect the disposition of assorted drugs by alteration the absolved biologic absorption through micellar encapsulation. In addition, it has been apparent that CrEL, as an basic basic of paclitaxel chemotherapy, modifies the toxicity contour of assertive anticancer agents accustomed concomitantly, by mechanisms added than active interference. A bright compassionate of the biological and pharmacological role of CrEL is capital to advice oncologists abstain side-effects associated with the use of paclitaxel or added agents application this vehicle. With the present development of assorted new anticancer agents, it is recommended that another conception approaches should be pursued to acquiesce a bigger ascendancy of the toxicity of the analysis and the pharmacological interactions accompanying to the use of CrEL.

Chemical nature:

Like Cremophor ELP, Cremophor ELP is a nonionic solubiliser fabricated by reactingcastor oil with ethylene oxide in a molar arrangement of 1 : 35. This is ollowed by apurifcation process

Pharmacopœias:Cremophor ELP meets the requirements of the accepted Ph.Eur. Monograph,“Macrogolglycerol Ricinoleate”. It aswell conorms to the latest monograph,“Polyoxyl 35 Castor Oil”.

Solubility:Cremophor ELP forms bright solutions in baptize and aswell dissolves in a widerange of amoebic solvents, such as ethanol, n-propanol, isopropanol, ethyl ace-tate, chloroorm, carbon tetrachloride, trichloroethylene, toluene and xylene.

More about:Cremophor ELP prices
From:Chem pharma

The Kollicoat SR 30 D Products

Abstract：A anew accessible polyvinylacetate aqueous dispersion, Kollicoat SR 30 D, was evaluated with account to its adeptness to attune the in vitro absolution of a awful water-soluble archetypal admixture (diphenhydramine hydrochloride) from nonpareil-based systems. Kollicoat SR 30D premixed with a called plasticizer (10% wt/wt propylene glycol, 2.5% triethyl citrate, or 2.5% dibutyl sebacate), talc, and red #30 basin dye was coated assimilate the biologic chaplet in an Aeromatic Strea I fluid-bed drier with a Wurster admit application basal spray. With propylene glycol as the plasticizer, increases in polymer blanket akin backward biologic absolution from chaplet in a stepwise appearance forth with credible permeability, advertence a constant absolution mechanism. Stability studies at 40 degrees C/75% RH appear bit-by-bit decreases in dissolution rate, and added abating studies added accepted the assurance of absolution kinetics on abating condition. Furthermore, the blazon of plasticizer was begin to play a key role. Unplasticized formulations apparent the fastest dissolution, followed by formulations plasticized with triethyl citrate, propylene glycol, and dibutyl sebacate. All 4 formulations (unplasticized and plasticized), nevertheless, appear a apparent aberration amid uncured and convalescent dissolution profiles. Kollicoat SR 30D has, thereby, been approved to finer arrest biologic absolution from nonpareil-based systems. However, called plasticizer blazon and consecutive abating action play important roles in authoritative biologic absolution from such a system.

The Kollicoat SR 30D chargeless filmwas able by casting technique. The filmtension was activated by the self-made filmtension analysis device. The furnishings of plasticizer and porogen on the compactness acreage and moisture-penetrability of the filmwere investigated. The after-effects adumbrated that the addendum arrangement and moisture-penetrability of the filmwere signifcantly added with the accretion of plasticizer (triethyl citrate, TEM). Three porogens [polyethylene glycol (PEG) 6000, polyvidone (PVP) K30 and hydroxy propyl methyl artificial (HPMC) E5] could advance the moisture-permeability, but had no significantinfluenceson the addendum ratio. Added tests showed that the bulk of PEG had no cogent influences on addendum arrangement and moisture-penetrability of the blur with％ TEM as plasticizer.

More about:Kollicoat SR 30 D supplier
From: Chem pharma

Properties of potassium borohydride

Potassium borohydride is white apart crumb or crystal. The about body of 1.178. Melting point 585 ℃, in a exhaustion of about 500 ℃ begins to decompose, abiding in air, no damp absorption. Potassium borohydride acrid in water, aqueous band-aid was acrimonious to 1000 ℃, the abounding absolution of hydrogen. Acrid in aqueous ammonia, hardly acrid in booze and ethanol, about baffling in ether, benzene, tetrahydrofuran, ether and added hydrocarbons. Abiding in an acrid environment, the case of asleep acerbic atomization of hydrogen. Mainly acclimated as a abbreviation abettor for the amoebic careful abridgement group; for aldehydes, ketones, acerbic chlorides of the abbreviation agent, and for hydrogen and added boron hydride salts. Also acclimated in analytic chemistry, cardboard industry, mercury-containing decay baptize analysis and constructed artificial potassium. For the pharmaceutical, artificial improvers, cardboard lurid bleaching. Sodium hydride, methyl borate columnist adjustment were acrid band-aid of sodium borohydride (i.e. hydrolysis footfall the consistent hydrolyzate), metering into the condensate catchbasin and acrimonious beneath active to 60 ℃, and potassium hydroxide insulation 1h; followed by cooling , still 12h; After centrifugation, the crystals were done with ethanol, broiled at 80 ℃ 16h, potassium borohydride to admission the accomplished product. The appurtenances on the close membranes, high respiratory tract, eyes and derma affliction strong. Inhalation can could could cause larynx and bronchial spasm, deepening and edema, actinic pneumonitis and pulmonary edema and death. Poisoning achievement afire sensation, coughing, wheezing, laryngitis, conciseness of breath, headache, abhorrence and vomiting. In case of fire, calefaction or acquaintance with oxidants, agitation acquired a accident of explosion. React with baptize or acids absolution hydrogen and calefaction can could could cause a fire.

Potassium borohydride leaked accelerated abandonment from air arising cadre to a safe area, and abreast and austere restrictions on access. Cut off the blaze source. Recommended emergency cadre cutting self-Pressurized respirators to abrasion careful clothing. Possible cut off the antecedent of leakage. Preventing admission to sewers, flood acquittal arroyo so akin space. Firefighters accept to abrasion clarify respirators (full cover), or abandoned respirators, cutting blaze careful clothing, blaze in the wind. Possible to move containers from the arena abandoned Department. Baptize cooling containers to accumulate the blaze until the end of fire. At the arena of containers, if any, change from the burden abatement assurance accessories accept choir accept to abandon immediately. Bankrupt operation, abounding ventilation. The abettor accept to go through specialized training, austere adherence to rules. Proposed operators abrasion clarify respirators (half-mask), abrasion assurance glasses, abrasion anti-static overalls, cutting elastic gloves. Accumulate abroad from fire, heat, abode smoking. Use explosion-proof blast systems and equipment. Anticipate breath arising into the abode air. Abstain acquaintance with acerbic agents, abbreviation agents, acrid contact. Filling should ascendancy the breeze rate, and a accomplishments accessory to anticipate the accession of changeless electricity. Handling of ablaze if ablaze unloading, packaging and containers to anticipate damage. Able with the adapted array and abundance of blaze accessories and emergency accessories leakage. Abandoned containers may be adverse residues. Store in a cool, aerial warehouse. Accumulate abroad from blaze and heat. Storage temperature should not beat 26 ℃. Accumulate alembic deeply closed. Should oxidants, abbreviation agents, bases stored alone and abstain bond reservoir. Explosion-proof lighting, blast facilities. Prohibit the use of simple to aftermath blaze of automated accessories and tools. Storage areas should be able with discharge acknowledgment accessories and abstracts acceptable host.

more about:  Potassium Borohydride supplier

from: Metal hydrides