Glibenclamide by increasing insulin levels, or the portal vein directly to the liver, inhibition of hepatic glycogenolysis and gluconeogenesis, reduced hepatic glucose production and output; oral absorption, high protein binding, was 95% after oral administration of 2 to 5 hour plasma concentration peak, continued for 24 hours. T1 / 2 was 10 hours. Metabolized in the liver by the hepatic and renal excretion of approximately 50%.
In ectopic pregnancy in the application:
Ectopic pregnancy is a common gynecological acute abdomen, the incidence increased significantly in recent years, but increased in patients without a child. With the fast and sensitive β-hCG detection technology to carry out, high-resolution B-application, make the most of unruptured ectopic pregnancy prior to the diagnosis, conservative treatment for drug provided the conditions [1], on the need to retain reproductive function in patients, choice of drugs and the best treatment is a question worth exploring. Conservative treatment of ectopic pregnancy has made great progress, has become a major means of treatment [2], and its advantage is that it not only kills the embryo tissue, without destroying the fallopian tubes, thereby maintaining tubal patency. At present, domestic and conservative about ectopic pregnancy reported that the majority of drug treatment used methotrexate (MTX).
However, methotrexate damage to the body's response to chemotherapy great many side effects. Mifepristone inception, gradually being used in the treatment of ectopic pregnancy, less the number of days for menopause, progesterone levels are relatively lower, mifepristone anti-pregnancy better. In this paper, 50 cases of ectopic pregnancy in patients with methotrexate (methotrexate, MTX) as the control, observation of mifepristone (mifepristone, Mif) the efficacy of treatment of ectopic pregnancy, to explore a safe, effective, convenient, less side effects of treatment.
Object of study and grouping May 1999 ~ October 2003 ectopic pregnancy diagnosed 50 patients hospitalized, the youngest 20 years old, maximum 41 years, mean 27 years, menopause time 38 to 65 days. Diagnosis is based on history, gynecological examination, serum β-hCG and B-ultrasound, except by curettage uterine pregnancy. Medication for: (a) unruptured ectopic pregnancy or tubal pregnancy rupture, but less bleeding; (2) B-ultrasound tubal pregnancy mass diameter 6000U / L and conservative treatment in patients with medication requirements, no taboo mifepristone licenser. (6) liver and kidney functions were normal, peripheral WBC, RBC, PLT were within normal range.
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From:Chem pharma
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