Clemastine fumarate is a white or almost white crystalline powder, odorless, slightly bitter taste. Clemastine fumarate (Clemastine Fumarate) is a Swiss Sandoz (Sandoz) company in the 1960s successfully developed antihistamines. Thereafter, in the United States, Japan, Germany, put on the market. This product is a typical, representative of the second generation H1 receptor antagonists, histamine clinically for the treatment cited by the various allergic diseases, is currently the world's best recognized antihistamines world.
Pharmacological effects:
Clemastine fumarate tablets of Shandong Institute of Pharmaceutical Industry in China developed the first of the original four new drugs, new drug to obtain a certificate, also received three years of administrative protection.
After forty years of clinical practice of foreign and domestic clinical validation summary, clemastine fumarate is a fast-acting, long-lasting, efficient, safe and reliable antihistamines. Clemastine fumarate tablets pharmacokinetics in humans showed that the oral absorption fast, effective after 30 minutes, quickly relieve symptoms, one hour after the plasma concentration reached the highest value compared with similar antihistamines such as astemizole, chlorine loratadine contrast, this product is the fastest effective. Its anti-histamine effect sustainable 12 hours, anti-histamine effect 10 times stronger than chlorpheniramine, drowsiness side effects (central role) is minimal. Treatment of allergic rhinitis total effective rate was 98%, the treatment of chronic urticaria urticaria cure rate 61.3%. Clemastine is not only basophils and lung tissue by the release of histamine antagonism, but at high concentrations toxic to cells also have a certain antagonism, drug on allergic diseases has many therapeutic effects. Mainly used in clinical allergic rhinitis, urticaria, eczema and other allergic dermatitis.
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From:Chem pharma
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