Mitomycin-C has antiseptic and anti-cancer effects

Mitomycin-C is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug.  This medication is classified as an "antitumor antibiotic."
Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.
Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
Treatment of adenocarcinoma of the stomach or pancreas.
Also used in treatment of anal, bladder, breast, cervical, colorectal, head and neck, and non-small cell lung cancer.

from:Acridine Raw Material

Brief introduction of Cyclosporin D

Chemical Name:   Cyclosporin D
Synonyms:   Val2-cyclosporine;
CAS r:   63775-96-2
 Formula:   C63H113N11O12
Appearance:   White Solid
Melting Point:   147-150°C
Mol. Weight:   1216.64
Storage:   -20°C Freezer
Stability:   No Data Available
Solubility:   Chloroform, Ethyl Aceatate
Category:   Peptides, Pharmaceuticals, Intermediates & Fine Chemicals,
Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.1,2 Cyclosporin D displays about 10% lower immunosuppressant activity than cyclosporine A.3,4 Cyclosporin D has been used as an internal standard for the quantification of cyclosporin A.
from:Acridine Raw Material

Introduction of 2,3-Difluoroaniline

name:2,3-Difluoroaniline
CAS : 4519-40-8
Formula: C6H5F2N
Flash point: 71°(159°F)
Formula weight: 129.11
Density: 1.274
Boiling point: 68-69°/12mm
Refractive Index: 1.5140
Molecular Weight: 129.11
Application
2,3-Difluoroaniline was used in the synthesis of ethyl 2-arylamino-4-trifluoromethylpyrimidine-5-carboxylate1.

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What is Ivabradine HCL？

Ivabradine hydrochloride（IvabradineHCL） is an accessible approach acquaintance of neuronal I(h) and accompanying cardiac I(f) channels, which are comprised of subunits of the hyperpolarisation-activated circadian nucleotide-gated (HCN) channels, in accurate HCN4. Ivabradine has antianginal activity. It lowers affection bulk and reduces myocardial oxygen demand.
Technical Information
Physical State: Solid
Solubility: Soluble in DMSO and Methanol
Storage: Store at -20° C
Melting Point: 193-196°C (lit.)
CAS Number: 148849-67-6
Purity: ≥99%
Molecular Weight: 505.05

Molecular Formula: C27H36N2O5 HCl
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Mechanism of Phosphatidic acid

Phosphatidic acid (PA) has alone afresh been articular as an important signaling atom in both plants and animals. Nonetheless, it already promises to battling the accent of the archetypal additional messengers Ca2+ and cAMP. In plants, its accumulation is triggered in acknowledgment to assorted amoebic and abiotic accent factors, including antibiotic infection, drought, salinity, acerbic and cold. In general, PA arresting assembly is fast (minutes) and transient. Recently, our compassionate of the role of PA accumulation in accent responses as a aftereffect of phospholipases C and D action has abundantly increased. Moreover, the aboriginal protein targets of PA accept been identified. Based on this contempo work, abeyant mechanisms by which PA provokes after furnishings are emerging.

Evidence is accumulating that Phosphatidic acid is a additional messenger. Its akin increases aural account of a advanced array of accent treatments including ethylene, wounding, antibiotic elicitors, osmotic and oxidative stress, and abscisic acid. Added arresting levels are rapidly attenuated by phosphorylating Phosphatidic acid to diacylglycerol pyrophosphate. Phosphatidic acid is the artefact of two signalling pathways, those of phospholipases C and D, the above in aggregate with diacylglycerol kinase. Families of these genes are now getting cloned from plants. Several after targets of Phosphatidic acid accept been identified, including protein kinases and ion channels.
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Elisa assay kits

Introduction of Anti-CBP

Description: CBP (also accepted as CREB-binding protein and CBP/p300) is a broadly bidding nuclear protein that contains a bromodomain, a ZZ-type zinc domain, and TAZ-type zinc fingers. This 265 kD acetyltransferase enzyme, acetylates histones and non-histone proteins like NCOA3 coactivator and mediates c-AMP gene acclimation by bounden to phosphorylated CREB. CBP and phosphorylated CREB activates archetype of c-AMP acknowledging genes; defects in CBP aftereffect in Rubinstein-Taybi affection (mental retardation, craniofacial defects, affection defects). CBP is activated by TCR signaling and is circuitous in TNF-α gene announcement and plays a axial role in acclimation gene responses to hypoxia. This protein is acetylated at assorted sites. CBP has been apparent to collaborate with NCOA6, androgen receptor, STAT6, SRC1, Csk, FKHR, and c-jun and to anatomy a circuitous with NCOA2, NCOA3, IKKA, IKKB, and IKBKG. In addition, CBP apparently forms a circuitous with HIF1A and EP300. The Poly6064 antibiotic has been apparent to be advantageous for Western blotting of the animal and abrasion CBP protein.
Other Names: CREB-binding protein, CREBBP, CBP/p300
Structure: Bromodomain, ZZ-type zinc domain, TAZ-type zinc fingers; 265 kD
Distribution: Nuclear protein, broadly expressed
Function: Acetyltransferase enzyme, acetylates histones and non-histone proteins like NCOA3 coactivator. Mediates c-AMP gene acclimation by bounden to phosphorylated CREB. CBP and phosphorylated CREB activates archetype of c-AMP acknowledging genes; defects result

Regulation: Activated by TCR signaling and circuitous in TNF-α gene expression, axial role in acclimation gene responses to hypoxia.

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Elisa assay kits