Description: CBP (also accepted as CREB-binding protein and CBP/p300) is a broadly bidding nuclear protein that contains a bromodomain, a ZZ-type zinc domain, and TAZ-type zinc fingers. This 265 kD acetyltransferase enzyme, acetylates histones and non-histone proteins like NCOA3 coactivator and mediates c-AMP gene acclimation by bounden to phosphorylated CREB. CBP and phosphorylated CREB activates archetype of c-AMP acknowledging genes; defects in CBP aftereffect in Rubinstein-Taybi affection (mental retardation, craniofacial defects, affection defects). CBP is activated by TCR signaling and is circuitous in TNF-α gene announcement and plays a axial role in acclimation gene responses to hypoxia. This protein is acetylated at assorted sites. CBP has been apparent to collaborate with NCOA6, androgen receptor, STAT6, SRC1, Csk, FKHR, and c-jun and to anatomy a circuitous with NCOA2, NCOA3, IKKA, IKKB, and IKBKG. In addition, CBP apparently forms a circuitous with HIF1A and EP300. The Poly6064 antibiotic has been apparent to be advantageous for Western blotting of the animal and abrasion CBP protein.
Other Names: CREB-binding protein, CREBBP, CBP/p300
Structure: Bromodomain, ZZ-type zinc domain, TAZ-type zinc fingers; 265 kD
Distribution: Nuclear protein, broadly expressed
Function: Acetyltransferase enzyme, acetylates histones and non-histone proteins like NCOA3 coactivator. Mediates c-AMP gene acclimation by bounden to phosphorylated CREB. CBP and phosphorylated CREB activates archetype of c-AMP acknowledging genes; defects result
Regulation: Activated by TCR signaling and circuitous in TNF-α gene expression, axial role in acclimation gene responses to hypoxia.
from:
Elisa assay kits
No comments:
Post a Comment