What is BAM-12P?

BAM-12P Soluble in water. The capacity of this canteen accept been accurately determined. Both the admiration and the canteen accept been siliconized. Do not attack to weight out a abate allocation of the contents. Theoretical conformational assay was acclimated to abstraction the spatial anatomy and conformational backdrop of the bovine adrenal medulla dodecaPeptide BAM-12P (Tyr1-Gly2-Gly3-Phe4-Met5-Arg6-Arg7-Val8-Gly9-Arg10-Pro11-Glu12). Twenty-three low-energy conformations of the BAM-12P courage were apparent to represent the spatial anatomy of the peptide. The changed structural botheration was solved. and constructed analogues of BAM-12P were proposed. the spatial structures of which accord to a set of low-energy potentially physiologically alive conformations of the accustomed dodecapeptide.

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From:polypeptide

Lithium aluminium hydride nature and structure

Lithium aluminium hydride is white or off-white crystalline powder, stable in dry air, moist air hydrolysis and cause combustion, soluble in diethyl ether, tetrahydrofuran and the like in an organic solvent; may aldehydes and ketones, acids, anhydrides, esters, quinones, acid chloride other reduced to an alcohol, a primary amine reduction of the nitrile, the halogenated hydrocarbon is a hydrocarbon reduction; but usually not the carbon - carbon double bonds hydrogenated.
Lithium aluminum hydride in a monoclinic crystal structure, space group (English: space group) is P21c, AlH4 tetrahedral ions. Lithium aluminum hydride, Li AlH4 with five adjacent tetrahedron, and with each one of the tetrahedron are bonded hydrogen atoms, with one of the four distance of 1.88-2.00Å, and fifth hydrogen distance longer, as 2.16Å [2], double pyramidal arrangement. Its cell parameters: a = 4.82, b = 7.81, c = 7.92 Å, α = γ = 90 ° and β = 112 °. At high pressure (> 2.2 GPa), the lithium aluminum hydride phase transition occurs, a β-LiAlH4. Right is lithium aluminum hydride cell model, purple ball represents a lithium atom, khaki regular tetrahedron represents AlH4.


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From:chemical metal

Adrenal Peptide E, bovine -related information

Adrenal Peptide E, bovine, a awful potent, 25-amino acerbic adrenal opioid peptide absolute both a [Met]enkephalin at the NH2-terminus and [Leu]enkephalin arrangement at the COOH-terminus, originally abandoned from bovine adrenal medulla [D. L. Kilpatrick, T. Taniguchi, B. N. Jones, A. S. Stern, J. E. Shively, J. Hullihan, S. Kimura, S. Stein, and S. Udenfriend (1981) Proc. Natl. Acad. Sci. USA 78, 3265-3268], is reported. The amalgam was able by the solid-phase adjustment employing the 4-(aminoacyloxymethyl)phenylacetamidomethyl(Pam)-copoly(styrene-1% divinylbenzene) resin. Two constructed strategies (N-indole formyl adequate vs caught tryptophan) were followed and after-effects compared and evaluated. It was bent that peptide E able with aegis of tryptophan (residues 13 and 14) was adopted and gave final artefact that was readily antiseptic by HPLC. The biological action of the constructed actual was begin to be agnate to the appear action of the accustomed compound.

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From:polypeptide

Neurotensin synthesis method

Neurotensin is a 13 amino acerbic neuropeptide that is active in the adjustment of luteinizing hormone and prolactin absolution and has cogent alternation with the dopaminergic system. Neurotensin was aboriginal abandoned from extracts of bovine hypothalamus based on its adeptness to could cause a arresting vasodilation in the apparent cutaneous regions of anesthetized rats.
Neurotensin is broadcast throughout the axial afraid system, with accomplished levels in the hypothalamus, amygdala and basis accumbens. It induces a array of effects, including: analgesia, hypothermia and added locomotor activity. It is aswell complex in adjustment of dopamine pathways. In the periphery, neurotensin is begin in endocrine beef of the baby intestine, area it leads to beard and bland beef contraction.

Sequence and biosynthesis：
Neurotensin shares cogent arrangement affinity in its 6 C-terminal amino acerbic residues with several added neuropeptides, including neuromedin N (which is acquired from the aforementioned precursor). This C-terminal arena is amenable for the abounding biological activity, the N-terminal allocation accepting a modulatory role. The neurotensin/neuromedin N forerunner can aswell be candy to aftermath ample 125-138 amino acerbic peptides with the neurotensin or neuromedin N arrangement at their C-terminus. These ample peptides arise to be beneath almighty than their abate counterparts, but are aswell beneath acute to abasement and may represent endogenous, abiding activators in a amount of pathophysiological situations.
The arrangement of bovine neurotensin was bent to be pyroGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH. Neurotensin is actinic as allotment of a 169-170 amino acerbic forerunner protein that aswell contains the accompanying neuropeptide neuromedin N.The peptide coding domains are amid in bike abreast the carboxyl terminal end of the forerunner and are belted and afar by commutual basal amino acerbic (lysine-arginine) processing sites.

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From:polypeptide

What is Physalaemin？

Physalaemin is a tachykinin peptide acquired from the Physalaemus frog, carefully accompanying to actuality P. Its anatomy was aboriginal elucidated in 1964.
Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a almighty vasodilator with hypotensive effects
Physalaemin (PHY), a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with top affinity. Both the aqueous and lipid-induced conformations of PHY accept been advised application two-dimensional nuclear alluring resonance techniques. These abstracts appearance that in baptize PHY prefers to be in an continued anatomy and that in the attendance of perdeuterated dodecylphosphocholine micelles, a film archetypal system, a circling anatomy is empiric from Pro4 to the C-terminus. Comparison of the structures ofPHYand added NK ligands forth with anatomy action studies appear on these peptide ligands suggests that circling courage structural burden is all-important for the bounden of these NK ligands to the assorted NK receptors. Furthermore, accord in the structures of these ligands suggests that these ligands have to be bounden forth the awful berserk face of the braid that contains the important berserk residues, Phe7, Leu10, and Met11, that are awful conserved in a lot of of the ligands.

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From:polypeptide

2-Ethoxybenzamide uses and production methods

Chemical properties :2-Ethoxybenzamide is white or almost white crystalline powder. Melting point 132-134 ℃. Soluble in chloroform, ethanol, acetone, insoluble in water, ether. Almost odorless, tasteless.
Uses: This product is anti-inflammatory drugs, the analgesic effect of salicylic acid amine 2.3 times, 7.5 times as aspirin. For the treatment of headaches, neuralgia, back pain, rheumatic joint pain and colds and so on. Rat oral LD50 of 1160mg/kg.
Uses: used as anti-inflammatory drugs for the treatment of fever, headache, neuralgia, joint pain, arthritis, pain, dysmenorrhea and other illnesses
Production methods: by salicylamide (C7H7NO2, [65-45-2]) by Ethyl derived. The salicylamide, solid sodium hydroxide, ethanol and placed against the pot, enclosed heated to 60-70 ℃, stirred for 30min, cooled to 30 ℃, adding ethyl bromide, and then sealed heating to 80-100 ℃, pressure is not More than 0.2MPa, reaction 3h. Reduced pressure, pH should be 8.5 or more. Filtered hot residue recovered sodium bromide. After most of the ethanol filtrate evaporated, add distilled water precipitated white crystals. Filtered, washed with water until neutral, dried, in o ethoxybenzamide. The yield of about 75%. Dibromoethane may be used instead of ethyl chloroethane reaction, but requires a higher pressure.


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From:chemical reagent

New peptide Phyllomedusin

Phyllomedusin is a new peptide of the tachykinin family, Phyllomedusin acerb affects the salivary glands, breach ducts, intestines, and bowels, and Phyllomedusin contributed to the agitated purging. Tachykinins are alive peptides which accelerate neurons, arm-twist behavioral responses, are almighty vasodilators and secretagogues, and Phyllomedusin arrangement (directly or indirectly) abounding bland muscles. Phyllomedusin is Secreted protein and Expressed by the derma glands. Phyllomedusin Belongs to the tachykinin family.


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From:polypeptide

Buccalin basic information

CAS Number: 116786-35-7
English name: BUCCALIN
English Synonyms: BUCCALIN; GMDSLAFSGGL-NH2; GLY-MET-ASP-SER-LEU-ALA-PHE-SER-GLY-GLY-LEU-NH2; H-GLY-MET-ASP-SER-LEU-ALA-PHE-SER -GLY-GLY-LEU-NH2
CBNumber: CB4199315
Formula: C45H72N12O15S
MW: 1053.19
MOL File: 116786-35-7.mol


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From:Natural Food Colors

Titanium Dioxide some explanations

Titanium dioxide, chemical formula TiO2, commonly known as titanium dioxide, used photocatalyst, cosmetics, can rely on UV disinfection and sterilization, are now being extensively developed, will have the opportunity to become the new industry. Rutile titanium dioxide can be extracted with an acid decomposition, or by the decomposition of titanium tetrachloride. Titania stable, for a large number of white pigment in paint, it has good covering power, and white lead are similar, but not as white lead will be black; it also has the same durability zinc white. Titanium dioxide is also used as a matting agent of enamel, can produce a very bright, hard and acid-resistant enamel overlay.
Titanium dioxide (chemical formula: TiO2), a white solid or powder form amphoteric oxide, is the best white pigment, commonly known as titanium dioxide. Strong adhesion of titanium dioxide, a chemical change is not easy, is always white. Especially valuable is nontoxic titanium dioxide. Its high melting point, is used to manufacture fire-resistant glass, glaze, enamel, clay, utensils and other high-temperature experiments.
Rutile titanium dioxide can be extracted with an acid decomposition, or by the decomposition of titanium tetrachloride. Titania stable, for a large number of white pigment in paint, it has good covering power, and white lead are similar, but not as white lead will be black; it also has the same durability zinc white. Titanium dioxide is also used as a matting agent of enamel, can produce a very bright, hard and acid-resistant enamel overlay.


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From:Natural Food Colors

Marigold Oleoresin basic information

Concept: Marigold Oleoresin is a marigold particles through subcritical obtained after low temperature extraction semifluid paste.
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Uses: mainly used for lutein extract from the processing of natural lutein or crystal. As food additives, colorants, feed additives.

Processing technology: Currently, the market sold mainly from marigold flower extract lutein deep processing, processing is as follows:
Marigold flowers harvest - hydrolysis - dehydration - drying - granulation - low leaching - lutein extract - packaging.
Lutein extract low temperature extraction process is subcritical temperature leaching (Regent Oil Engineering Co., Ltd. Anyang patented technology), obtained by the method subcritical cryogenic extraction of active ingredients lutein extract indicators relative yield of trans-lutein higher, can effectively reduce the waste of resources should be promoted processing methods.



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From:Natural Food Colors

Fucoxanthin has a slimming effect

Fucoxanthin also known as pheophytin for brown algae diatoms, golden algae and green algae contained yellow pigment in photosynthesis photochemical system Ⅱ. Separation may be a red-brown crystals, which is a leaf zeaxanthin, is to render a brown brown algae substance brown algae can be said specific dye, scattered sometimes appeared in diatoms and other algae . Sometimes with fucoxanthin (phycophaein also translated pheophytin) confused, but fucoxanthin (phycophaein) that is unique to a water-soluble alginate dye class, and seems to be a hypothetical substance seems to refer to death in plants After the class contained in the brown algae as a phenolic substance is oxidized to form a brown substance, they are essentially different.
Weight loss: weight loss, obviously, fucoxanthin are two ways to eliminate fat accumulation. Fucoxanthin can activate called UCP1 protein that can promote fat decomposition. It also stimulates the liver to produce cholesterol levels DHA.
Japan's Hokkaido University researchers confirmed that fucoxanthin - a brownish algae pigment substance - will become a panacea for weight loss. Researchers conducted experiments on mice found that by regularly adding fucoxanthin containing food additives, 5-10% weight loss in mice. Scientists have only a total of over two hundred mice were studied. In the experiment, scientists found that fucoxanthin are two ways to eliminate fat accumulation. Fucoxanthin can activate called UCP1 protein that can promote fat decomposition. It also stimulates the liver to produce cholesterol levels DHA. Scientists have also confirmed that the use of a concentrated fucoxanthin animal food additives do not cause any side effects or other addiction.


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From:Natural Food Colors

Turmeric yellow water soluble Profile

Turmeric Turmeric is Zingiberaceae species, in some Asian countries called turmeric or kunyit. Its roots are ground into a deep yellow curry powder spices is one major, also used in Southeast Asia dishes tasted bitter and spicy, a little earthy. Main ingredient curcumin (curcumin) has some health effects, so turmeric also appeared in the Han medicine timber.

Function of taste: turmeric spicy, bitter, warm. Main function is expelling gas line.
Concurrent turmeric expelling blood and qi stagnation, into two by the liver and spleen, liver and spleen two good break through the blood stasis and qi nodal function blood stasis, qi pain.

Pharmacology: According to recent research reports, turmeric hepatitis virus inhibition, to improve the role of parenchymal lesions.
Turmeric excitatory role of the uterus, uterine contractions paroxysmal; can promote bile secretion in anesthetized dogs, but are less effective and lasting.

Chinese medicine Turmeric traits: Herbal Turmeric irregular oval, cylindrical or fusiform, often curved, some with short forked branches, length 2 ~ 5cm, diameter of 1 ~ 3cm. Surface deep yellow, rough, wrinkled texture and obvious links, and a round branching and fibrous scar marks. Quality solid and difficult to break, the cross section brownish yellow to golden yellow, horn-like, wax-like luster, ringed evident within the cortex, vascular bundles scattered punctate. Specific gas smell, bitter, acrid.



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Albuterol sulfate use and some considerations

Purpose:
Albuterol sulfate indications: bronchial asthma, asthmatic bronchitis and emphysema.
Role: Selective bronchial smooth muscle excitement on β2-receptors, the bronchial smooth muscle relaxation, thereby lifting the bronchial smooth muscle spasm. Adverse reactions: mainly on the heart and central nervous system stimulant, such as headache, dizziness, insomnia, occasional muscle and finger tremor, palpitations, blood pressure fluctuations. Long-term use can produce drug resistance, may aggravate asthma.

Note:
Pregnancy Category C. Cardiovascular dysfunction, hypertension, hyperthyroidism, diabetes and pregnancy in patients with caution. Increased use of inhaled short-acting b2-agonists to control symptoms, showing attenuation of asthma control, if this happens, you should re-evaluate the patient's treatment. Control of asthma sudden and gradual decay, the patient's life may be in danger, began to implement or increase should be considered corticosteroid treatment. If the patient has this crisis, should exercise the greatest tidal volume of daily monitoring. Home treatment of patients receiving the goods should note that if the soothing effect or duration than usual reduced, it should not increase the dose or administration of their own times.
For known to use large doses of other sympathomimetic drugs patients should be careful.
Patients suffering from thyrotoxicosis should be matched with caution b2-agonist therapy (mainly used for injection and aerosol).
There are potentially serious hypokalemia disease, if the patient is suffering from acute severe asthma, should pay particular attention this adverse effect because while taking xanthine inducing drugs, steroids and diuretics, and the emergence of hypoxia will involve hypokalemia cases were transferred, in case of such situation, you must be careful monitoring of serum potassium levels.
On pregnancy and lactation: women during pregnancy should not inhale the drug, if diagnosed by a doctor that the use of this drug in pregnant women may result in benefits outweigh the risk to the fetus, may consider using this medicine. Avandia women, postpartum bleeding emulsion may have the goods hormone drugs, so unless the expected benefits outweigh the possible hazards arising from, or for women to breastfeed infants should not inhale the drug, has yet to prove that breast milk whether the product in newborn babies harmful.


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From:Chem pharma