Physalaemin is a tachykinin peptide acquired from the Physalaemus frog, carefully accompanying to actuality P. Its anatomy was aboriginal elucidated in 1964.
Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a almighty vasodilator with hypotensive effects
Physalaemin (PHY), a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with top affinity. Both the aqueous and lipid-induced conformations of PHY accept been advised application two-dimensional nuclear alluring resonance techniques. These abstracts appearance that in baptize PHY prefers to be in an continued anatomy and that in the attendance of perdeuterated dodecylphosphocholine micelles, a film archetypal system, a circling anatomy is empiric from Pro4 to the C-terminus. Comparison of the structures ofPHYand added NK ligands forth with anatomy action studies appear on these peptide ligands suggests that circling courage structural burden is all-important for the bounden of these NK ligands to the assorted NK receptors. Furthermore, accord in the structures of these ligands suggests that these ligands have to be bounden forth the awful berserk face of the braid that contains the important berserk residues, Phe7, Leu10, and Met11, that are awful conserved in a lot of of the ligands.
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From:polypeptide
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